ISOLUTE® Mixed-mode SPE
ミックスモード充填剤
ISOLUTEミックスモード充填剤の一覧です。
ISOLUTE HCX, HCX-3 AND HCX-5
Figure 2: Multiple (hydrophobic and cation exchange) interactions on ISOLUTE HCX, HCX-3 and HCX-5
ISOLUTE HCX (sorbent ref. 902)
Description
Mixed-mode C8 and strong cation exchange functionalized silica. Manufactured using trifunctional silanes. Non end-capped.
Average Particle Size
50μm
Nominal Porosity
60A
Comments
First choice for generic methods for high purity basic drug extracts
Chemistry Data Sheet
- TN116（PDF 68.5KB）
ISOLUTE ミックスモード充填剤による生体サンプルからの塩基性化合物の一般的抽出メソッド（英文資料） - TN125（PDF 67.2KB）
ISOLUTE HCXミックスモード充填剤によるサンプル前処理（英文資料）
ISOLUTE HCX-3 (sorbent ref. 905)
Description
Mixed-mode C18 and strong cation exchange functionalized silica. Manufactured using trifunctional silanes. Non end-capped.
Average Particle Size
50μm
Nominal Porosity
60A
Comments
Alternative to ISOLUTE HCX where more rententive non-polar sorbent is required for rentention of polar compounds.
Chemistry Data Sheet
- TN116（PDF 68.5KB）
ISOLUTE ミックスモード充填剤による生体サンプルからの塩基性化合物の一般的抽出メソッド（英文資料）
ISOLUTE HCX-5 (sorbent ref. 906)
Description
Mixed-mode C4 and strong cation exchange functionalized silica. Manufactured using trifunctional silanes. Non end-capped.
Average Particle Size
50μm
Nominal Porosity
60A
Comments
Alternative to ISOLUTE HCX, where less retentive non-polar sorbent can provide cleaner extracts.
Chemistry Data Sheet
- TN116（PDF 68.5KB）
ISOLUTE ミックスモード充填剤による生体サンプルからの塩基性化合物の一般的抽出メソッド（英文資料）
ISOLUTE HCX-Q (sorbent ref. 986)
Description
Mixed-mode C8 and weak cation exchange functionalized silica. Manufactured using trifunctional silanes. Non end-capped.
Average Particle Size
50μm
Nominal Porosity
60A
Comments
Generic method for high purity extracts of quaternary amines or strongly basic drugs.
Chemistry Data Sheet
- TN129（PDF 69.1KB）
ISOLUTE HCX-Qによる生体サンプルからの第4級アミン及び多塩基化合物の一般的な抽出メソッド（英文資料）
ISOLUTE HAX (sorbent ref. 903)
Figure 3: Multiple (hydrophobic and anion exchange) interactions on ISOLUTE HAX
Description
Mixed-mode C8 and strong anion exchange functionalized silica. Manufactured using trifunctional silanes. Non end-capped.
Average Particle Size
50μm
Nominal Porosity
60A
Comments
Generic method for high purity acidic drug extracts
Chemistry Data Sheet
- TN127（PDF 275.2KB）
ISOLUTE HAXを使用したサンプル前処理（英文資料）
ISOLUTE Multimode (sorbent ref. 904)
Description
Mixed-mode column containing both non-polar (C18), strong cation exchange (-SO3-) and strong anion exchange (-NR3+) functional groups.
Average Particle Size
50μm
Nominal Porosity
60A